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Multisystem Physiologic Impairments and Changes in Gait Speed of Older Adults

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Multisystem Physiologic Impairments and Changes in Gait Speed of Older Adults

Auteurs : Andrea L. Rosso ; Jason L. Sanders ; Alice M. Arnold ; Robert M. Boudreau ; Calvin H. Hirsch ; Michelle C. Carlson ; Caterina Rosano ; Stephen B. Kritchevsky ; Anne B. Newman

Source :

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 2014.

RBID : PMC:4351395

Descripteurs français

KwdFr :
- Démarche (physiologie), Encéphale (physiologie), Facteurs de l'âge, Facteurs temps, Femelle, Glucose (métabolisme), Humains, Indicateurs d'état de santé, Mâle, Phénomènes physiologiques cardiovasculaires, Poumon (physiologie), Rein (physiologie), Sensibilité et spécificité, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes, Évaluation gériatrique.
MESH :
- métabolisme : Glucose.
- physiologie : Démarche, Encéphale, Poumon, Rein.
- Facteurs de l'âge, Facteurs temps, Femelle, Humains, Indicateurs d'état de santé, Mâle, Phénomènes physiologiques cardiovasculaires, Sensibilité et spécificité, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes, Évaluation gériatrique.

English descriptors

KwdEn :
- Age Factors, Aged, Aged, 80 and over, Brain (physiology), Cardiovascular Physiological Phenomena, Cohort Studies, Female, Gait (physiology), Geriatric Assessment, Glucose (metabolism), Health Status Indicators, Humans, Kidney (physiology), Lung (physiology), Male, Sensitivity and Specificity, Time Factors.
MESH :
- chemical , metabolism : Glucose.
- physiology : Brain, Gait, Kidney, Lung.
- Age Factors, Aged, Aged, 80 and over, Cardiovascular Physiological Phenomena, Cohort Studies, Female, Geriatric Assessment, Health Status Indicators, Humans, Male, Sensitivity and Specificity, Time Factors.

Abstract

Background:

Slowed gait is an important health indicator in older adults but a single identifiable cause is often lacking. We assessed whether a summary index measuring impairments across multiple physiologic systems was associated with slowed gait in older individuals.

Methods:

Data from the Cardiovascular Health Study (n = 3,010) were used to assess associations between baseline physiologic index (measuring vasculature, brain, kidneys, lungs, and glucose metabolism; range 0–10 with 0–2 points/system and lower score indicating higher function) and annual gait speed (m/s) over 6 years. Participants with complete data on the physiologic index and at least two gait speed measures were included. Mean gait speed and 95% confidence intervals (CI) by category of index were calculated using mixed effects models.

Results:

Those with scores of three or higher on the index had significantly slower gait speed at baseline compared to those with scores of 0–2 (7–10: mean speed = 0.83 m/s, 95% CI: 0.80, 0.84; 0–2: mean speed = 1.01 m/s, 95% CI: 0.99, 1.03). Those with higher indices also had faster decline in gait speed compared to those with lower scores after adjustment for demographic and health characteristics (7–10: change in speed = −0.020 m/s/year, 95% CI: −0.024, −0.016; 0–2: change in speed= −0.010 m/s/year, 95% CI: −0.014, −0.006).

Conclusions:

Greater impairment across five organ systems was associated with slower gait speed and greater declines in gait speed over 6 years. Impairments accumulated over multiple physiologic systems may make older adults more vulnerable to slow gait speed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351395

DOI: 10.1093/gerona/glu176
PubMed: 25380599
PubMed Central: 4351395

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain (physiology)</term>
<term>Cardiovascular Physiological Phenomena</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Gait (physiology)</term>
<term>Geriatric Assessment</term>
<term>Glucose (metabolism)</term>
<term>Health Status Indicators</term>
<term>Humans</term>
<term>Kidney (physiology)</term>
<term>Lung (physiology)</term>
<term>Male</term>
<term>Sensitivity and Specificity</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Démarche (physiologie)</term>
<term>Encéphale (physiologie)</term>
<term>Facteurs de l'âge</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Glucose (métabolisme)</term>
<term>Humains</term>
<term>Indicateurs d'état de santé</term>
<term>Mâle</term>
<term>Phénomènes physiologiques cardiovasculaires</term>
<term>Poumon (physiologie)</term>
<term>Rein (physiologie)</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de cohortes</term>
<term>Évaluation gériatrique</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glucose</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Démarche</term>
<term>Encéphale</term>
<term>Poumon</term>
<term>Rein</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain</term>
<term>Gait</term>
<term>Kidney</term>
<term>Lung</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cardiovascular Physiological Phenomena</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Health Status Indicators</term>
<term>Humans</term>
<term>Male</term>
<term>Sensitivity and Specificity</term>
<term>Time Factors</term>
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<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indicateurs d'état de santé</term>
<term>Mâle</term>
<term>Phénomènes physiologiques cardiovasculaires</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background:</title>
<p>Slowed gait is an important health indicator in older adults but a single identifiable cause is often lacking. We assessed whether a summary index measuring impairments across multiple physiologic systems was associated with slowed gait in older individuals.</p>
</sec>
<sec><title>Methods:</title>
<p>Data from the Cardiovascular Health Study (<italic>n</italic>
 = 3,010) were used to assess associations between baseline physiologic index (measuring vasculature, brain, kidneys, lungs, and glucose metabolism; range 0–10 with 0–2 points/system and lower score indicating higher function) and annual gait speed (m/s) over 6 years. Participants with complete data on the physiologic index and at least two gait speed measures were included. Mean gait speed and 95% confidence intervals (CI) by category of index were calculated using mixed effects models.</p>
</sec>
<sec><title>Results:</title>
<p>Those with scores of three or higher on the index had significantly slower gait speed at baseline compared to those with scores of 0–2 (7–10: mean speed = 0.83 m/s, 95% CI: 0.80, 0.84; 0–2: mean speed = 1.01 m/s, 95% CI: 0.99, 1.03). Those with higher indices also had faster decline in gait speed compared to those with lower scores after adjustment for demographic and health characteristics (7–10: change in speed = −0.020 m/s/year, 95% CI: −0.024, −0.016; 0–2: change in speed= −0.010 m/s/year, 95% CI: −0.014, −0.006).</p>
</sec>
<sec><title>Conclusions:</title>
<p>Greater impairment across five organ systems was associated with slower gait speed and greater declines in gait speed over 6 years. Impairments accumulated over multiple physiologic systems may make older adults more vulnerable to slow gait speed.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Arnold, Alice M" sort="Arnold, Alice M" uniqKey="Arnold A" first="Alice M." last="Arnold">Alice M. Arnold</name>
<name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name>
<name sortKey="Carlson, Michelle C" sort="Carlson, Michelle C" uniqKey="Carlson M" first="Michelle C." last="Carlson">Michelle C. Carlson</name>
<name sortKey="Hirsch, Calvin H" sort="Hirsch, Calvin H" uniqKey="Hirsch C" first="Calvin H." last="Hirsch">Calvin H. Hirsch</name>
<name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name>
<name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
<name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name>
<name sortKey="Rosso, Andrea L" sort="Rosso, Andrea L" uniqKey="Rosso A" first="Andrea L." last="Rosso">Andrea L. Rosso</name>
<name sortKey="Sanders, Jason L" sort="Sanders, Jason L" uniqKey="Sanders J" first="Jason L." last="Sanders">Jason L. Sanders</name>
</noCountry>
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Multisystem Physiologic Impairments and Changes in Gait Speed of Older Adults

Multisystem Physiologic Impairments and Changes in Gait Speed of Older Adults

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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